Researchers from IIT Delhi and AIIMS have created an ingestible device capable of directly sampling microbes from the small intestine.
About the size of a grain, the device addresses long-standing difficulties in analysing bacteria that inhabit the upper gastrointestinal tract.
This newly developed swallowable tool provides a minimally invasive option for intestinal microbiome studies. It stays tightly sealed while passing through the stomach and activates only after reaching the small intestine, where it gathers microbial samples. The device then reseals, preserving the collected material as it moves through the rest of the digestive system.
The technology relies on an enteric-coated gelatin capsule that can tolerate the stomach’s highly acidic conditions. Once the capsule encounters the higher pH environment of the intestine, the coating dissolves, enabling intestinal fluid to enter through a specially designed inlet linked to internal activation and sampling chambers.
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